Defining the proliferative phase endometrial defect  

Oleh:

Bromer, Jason G. ; Aldad, Tamir S. ; Taylor, Hugh S.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 03 (Mar. 2009), page 698-704 .
Topik: Endometrium; endometrial development; proliferative phase; clomiphene; FSH; endometriosis; polycystic ovary syndrome; recurrent pregnancy loss

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective To evaluate proliferative phase endometrial development in a heterogeneous infertility population. Design Retrospective study. Setting University-based infertility practice. Patient(s) Two hundred forty-six treatment cycles. Intervention(s) Clomiphene citrate or FSH ovarian stimulation, followed by IUI or IVF. Main Outcome Measure(s) Endometrial thickness according to transvaginal ultrasonography; clinical pregnancy rate. Result(s) Endometrial growth began from a nadir of approximately 4.5 mm on cycle day 4 and increased linearly to a plateau of approximately 10 mm on cycle day 9. This same pattern was observed in all cycles, regardless of pregnancy, drug, or underlying diagnosis. Follicle-stimulating hormone–stimulated cycles showed a significantly increased endometrial thickness compared with clomiphene citrate cycles (10.1 vs. 8.3 mm). Maximum endometrial thickness achieved showed a correlation with age, body mass index, and maximum E2 level. Subjects who carried a primary diagnosis of polycystic ovary syndrome, endometriosis, or recurrent pregnancy loss all achieved a significantly lower peak endometrial thickness than control subjects. There was a trend toward increased endometrial thickness in cycles resulting in pregnancy compared with those not (10.1 vs. 9.6 mm, respectively). Conclusion(s) Endometrial development follows a predictable pattern, with a plateau in growth at cycle day 9. Diseases associated with infertility manifest a proliferative phase defect that can be recognized clinically.

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