Declining ovarian reserve adversely influences granulosa cell viability  

Oleh:

Greenseid, Keri ; Jindal, Sangita ; Zapantis, Athena

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 06 (Jun. 2009), page 2611-2615.
Topik: Ovarian reserve; granulosa cell; mural; cumulus; follicle stimulating hormone

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To identify if declining ovarian reserve adversely influences granulosa cell (GC) parameters in patients undergoing IVF. Design Prospective study. Setting Academic IVF Center. Patient(s) Twenty-four women undergoing IVF. Intervention(s) Mural and cumulus GCs were harvested (at time of egg retrieval). Main Outcome Measure(s) Influence of ovarian reserve, reflected by maximal basal FSH levels, on GC (cumulative, mural, and cumulus) counts and viability were investigated. Result(s) The FSH levels demonstrated an inverse correlation with cumulative and mural, but not cumulus, GC viability. Adverse influence of increasing FSH on cumulative GC viability was independent of patient's age. The GC counts were uninfluenced by ovarian reserve status. Neither GC count nor viability demonstrated any relationship with clinical pregnancy after IVF. Conclusion(s) We observed an adverse association between declining ovarian reserve and GC parameters. We believe these findings may partly explain the suboptimal reproductive performance in these women.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali