Letrozole co-treatment in infertile women 40 years old and older receiving controlled ovarian stimulation and intrauterine insemination  

Oleh:

Bedaiwy, Mohamed A ; Shokry, Mahmoud ; Mousa, Noha

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 06 (Jun. 2009), page 2501-2507 .
Topik: Letrozole; FSH; controlled ovarian hyperstimulation; intrauterine insemination; advanced reproductive age

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To investigate the effect of a combination of letrozole and gonadotropins in advanced reproductive age infertile women who were treated with IUI. Design A retrospective case control study. Setting A private practice affiliated with an academic institute. Patient(s) Infertile women 40 years old and older who were treated with IUI and controlled ovarian hyperstimulation (COH) using either letrozole in combination with FSH (n = 90) or FSH alone (n = 69). Main Outcome Measure(s) Pregnancy rates (PR), mature follicles, serum levels of E2, P, LH, endometrial thickness, rates of cycle cancellation, and FSH dose. Result(s) Pregnancy rates were comparable between the letrozole–FSH co-treatment group and the FSH alone group. Significantly fewer cycles were cancelled in the letrozole co-treatment group. The E2 levels and the number of follicles were significantly higher in the FSH-only group. Serum levels of LH were significantly higher in the co-treatment group on cycle day 7. The P levels were significantly higher in the FSH alone group on the day of hCG administration. Conclusion(s) Letrozole co-treatment compared with using FSH alone has significantly modified the cycle characteristics without reducing PRs and could be of potential benefit in IUI cycles in older infertile women.

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