Cannabinoids inhibit the respiration of human sperm  

Oleh:

Badawy, Zaki S ; Chohan, Kazim R. ; Whyte, Donna A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Fertility and Sterility (keterangan: ada di ClinicalKey) vol. 91 no. 06 (Jun. 2009), page 2471-2476 .
Topik: Cannabinoids; respiration; mitochondria; sperm

Ketersediaan

Perpustakaan FK Nomor Panggil: F02.K.2009.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective To investigate the effects of the psychotropic compounds ?9-tetrahydrocannabinol (?9-THC) and ?8-tetrahydrocannabinol (?8-THC) on sperm mitochondrial O2 consumption (respiration). Setting State University of New York Upstate Medical University, Syracuse, New York. Patient(s) Forty-one men who visited the andrology laboratory for fertility evaluation. Intervention(s) None. Main Outcome Measure(s) A phosphorescence analyzer that measures O2 concentration in sperm suspensions as a function of time was used to measure respiration. Result(s) An immediate decline in the rate of respiration was observed when ?9-THC or ?8-THC was added to washed sperm. The inhibition was concentration dependent, and ?9-THC was the more potent of the two compounds. Respiration was much less affected when ?9-THC or ?8-THC was added to neat semen, suggesting the presence of protective factors in seminal plasma. Both compounds inhibited the respiration of isolated mitochondria, illustrating that direct mitochondrial damage is likely the primary mechanism of action. Conclusion(s) The two main active cannabinoids of the marijuana plant, ?9- and ?8-THC, are potent inhibitors of mitochondrial O2 consumption in human sperm. These findings emphasize the adverse effects of these toxins on male fertility. The cytoprotective capacity of seminal plasma deserves further investigation.

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