Red blood cell {delta}15N: a novel biomarker of dietary eicosapentaenoic acid and docosahexaenoic acid intake  

Oleh:

O'Brien, Diane M ; Kristal, Alan R ; Jeannet, M Alyssa ; Wilkinson, Michael J ; Bersamin, Andrea ; Luick, Bret

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 89 no. 03 (Mar. 2009), page 913.
Topik: Nutritional epidemiology and public health

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2009.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: The long-chain omega-3 (n–3) fatty acids derived from fish, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with a reduced risk of cardiovascular disease and other chronic diseases. Study of the associations between EPA and DHA intake and disease requires a valid biomarker of dietary intake; however, the direct measurement of tissue fatty acid concentrations is expensive and time consuming. Objective: Because the nitrogen stable isotope ratio (15N/14N, expressed as {delta}15N) is elevated in fish, we investigated whether {delta}15N is a valid alternative biomarker of EPA and DHA intake. Design: We examined the relation between red blood cell (RBC) {delta}15N and RBC EPA and DHA in a community-based sample of 496 Yup'ik Eskimos with widely varying intake of n–3 fatty acids. We also assessed the correlation between {delta}15N and dietary EPA and DHA intake based on 24-h dietary recalls and 3-d food records completed by a subset of 221 participants. Results: RBC {delta}15N was strongly correlated with RBC EPA and DHA (r = 0.83 and 0.75, respectively). These correlations differed only modestly by sex and age class. RBC {delta}15N also correlated with dietary EPA and DHA intake (r = 0.47 and 0.46, respectively) and did not differ by sex and age. Conclusions: The results strongly support the validity of RBC {delta}15N as a biomarker of EPA and DHA intake. Because the analysis of RBC {delta}15N is rapid and inexpensive, this method could facilitate wide-scale assessment of EPA and DHA intake in clinical and epidemiologic studies.

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