Detail Oral nanoparticle-based antituberculosis drug delivery to the brain in an experimental model (in Journal of Antimicrobial Chemotherapy 57) Bibliografi Author: Pandey, Rajesh ; Khuller, G.K. Topik: Poly-lactide-co-glycolide; Bioavailability; Pharmacodynamics; Chemotherapy; Nanotechnology Bahasa: (EN )     Penerbit: Oxford University Press     Tempat Terbit: London    Tahun Terbit: 2006     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 1146.pdf (313.65KB; 1 download) Abstract Objectives: To evaluate the potential of orally administered poly-lactide-co-glycolide (PLG, a synthetic polymer) nanoparticleencapsulated antituberculosisdrugs(ATDs)(rifampicin+isoniazid+pyrazinamide+ ethambutol) for cerebral drug delivery in a murine model. Methods: The formulation was prepared using the multiple emulsion technique and administered orally to mice for biodistribution, pharmacokinetic and chemotherapeutic studies. Results: A single oral dose of the formulation to mice could maintain sustained drug levels for 5–8 days in the plasma and for 9 days in the brain. There was a significant improvement in the pharmacokinetic para-meters such as mean residence time and relative bioavailability as compared with free drugs. The pharmacodynamic parameters such as the ratio of area under the curve to minimum inhibitory concentration (AUC/MIC) and the time up to which MIC levels were maintained in plasma (TMIC) were also improved. In Mycobacterium tuberculosis H37Rv infected mice, five oral doses of the nanoparticle formulation admin-istered every 10th day resulted in undetectable bacilli in the meninges, as assessed on the basis of cfu and histopathology. Conclusions: Polymeric nanoparticles bear significant potential for ATD delivery to the brain. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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