Seroepidemiology of Japanese Encephalitis Virus Infection in Bats and Pigs in West Kalimantan, Indonesia  

Oleh:

Sendow, Indrawati ; Adjid, Raden Muhamad Abdul ; Breed, Andrew Christopher ; Daniels, Peter ; Darminto ; Field, Hume Ernest ; Lunt, Ross ; Mustafa, Abdul Manaf ; Triratnawati, Atik

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Microbiology Indonesia vol. 2 no. 2 (Aug. 2008), page 79-83.
Topik: Japanese encephalitis; antibodies; bats; pigs
Fulltext: Indrawati Sendow.pdf (223.59KB)

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: MM78.2 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Japanese encephalitis virus is a significant cause of fatal encephalitis in humans, particularly affecting infants and young children. The virus is mosquito-vectored, and a wide range of vertebrate hosts has been implicated in its ecology. Infection of domestic pigs is epidemiologically linked to spread of the virus to humans. In this serological study evidence of Japanese encephalitis virus infection has been identified from a survey of 610 pigs from 6 districts in West Kalimantan Province, Indonesia (Pontianak, Landak, Sanggau, Sambas, Bengkayang and Singkawang). Some 84 Pteropus vampyrus bats from Pontianak district and 15 Cynopterus brachyotis bats from Singkawang district were studied. As much as 84% of pig sera and 12% of P. vampyrus sera reacted on Japanese encephalitis virus and flavivirus C-ELISA. None of the C. brachyotis showed evidence of infection. JEV infection appears to be endemic in pigs in Kalimantan and encephalitis cases due to JEV have been reported in humans. The presence of JE antibodies in P. vampyrus suggests that this species may act as a natural reservoir host of JE. While the latter does not mean that flying foxes are the source of infection for pigs, our finding of increased JE seroprevalence in pigs combined with increased incidence of human cases, clearly demonstrates the need for ongoing surveillance and further investigation of the epidemiology and ecology of this virus. This is the first report of apparent Japanese encephalitis virus infection in P. vampyrus, and adds to the list of zoonoses associated with this species. The findings indicate a high Japanese encephalitis virus prevalence indomestic pigs and identifies a significant risk of ‘spill-over’ human infection and disease.

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