Pengobatan Filariasis Limfatik dengan Diethylcarbamazine (DEC), Albendazole, Kombinasi Dec-Albendazole dan Ivermektin-Albendazole  

Oleh:

Kesetyaningsih, Tri Wulandari

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Jurnal Kedokteran YARSI vol. 11 no. 01 (Jan. 2003), page 77-80.
Topik: Drugs; Lymphatic Filariasis; Albendazole; Ivermectin; DEC
Fulltext: J51; 2003; 11; 1; 77.win.pdf (2.03MB)

Ketersediaan

Perpustakaan PKPM Nomor Panggil: J51 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Lymphatic filariasis is still a big problem of public health in endemic country, included Indonesia. The drug of choice for lymphatic filariasis treatment is diethylcarbamazine (DEC). However, a controlled study of lymphatic filariasis through mass treatment by using DEC showed significant constraint due to the severe side effect of the drug. Based on that reason, it is important to look for better drug for lymphatic filariasis treatment. The new drug must be effective killed the microfilarias and macrofilarias, no side effect and effective in single — oral dose. This is a literature study that up dating most recent studies on that issue. The treatment by using low dosage in long time of DEC or by using 0,2% DEC-salt was effective to Wuchereria bancrofti, but there are still some obstacle infield application. Albendazole combined with DEC or ivermectin are new potential alternative drug for lymphatic filariasis treatment. Albendazole - DEC combination showed more effective to microfilaria and macrofilaria Brugia malayi, while albendazole - ivermectin combination were effective to microfilaria and macrofilaria Wuchereria bancrofti.

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