The methodology of self-controlled case series  

Oleh:

Whitaker, Heather J ; Hocine, Mounia N ; Farrington, C Paddy

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Statistical Methods in Medical Research vol. 18 no. 1 (Feb. 2009), page 7–26.
Fulltext: 7AR181.pdf (266.39KB)

Isi artikel

The self-controlled case series method is increasingly being used in pharmacoepidemiology, particularly in vaccine safety studies. This method is typically used to evaluate the association between a transient exposure and an acute event, using only cases. We present both parametric and semiparametric models using a motivating example on MMR vaccine and bleeding disorders. We briefly describe approaches for interferent events and a sequential version of the method for prospective surveillance of drug safety. The efficiency of the self-controlled case series method is compared to the that of cohort and case control studies. Some further extensions, to long or indefinite exposures and to bivariate counts, are described.

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