Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat  

Oleh:

Grundmann, Hajo ; Aires-de-Sousa, Marta ; Boyce, John ; Tiemersma, Edine

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Lancet (keterangan: ada di Proquest) vol. 368 no. 9538 (Sep. 2006), page 874.

Ketersediaan

Perpustakaan FK Nomor Panggil: L01.K.2006.05 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Staphylococcus aureus is a gram-positive bacterium that colonises the skin and is present in the anterior nares in about 25—30% of healthy people.1 Dependent on its intrinsic virulence or the ability of the host to contain its opportunistic behaviour, S aureus can cause a range of diseases in man. The bacterium readily acquires resistance against all classes of antibiotics by one of two distinct mechanisms: mutation of an existing bacterial gene or horizontal transfer of a resistance gene from another bacterium. Several mobile genetic elements carrying exogenous antibiotic resistance genes might mediate resistance acquisition.2 Of all the resistance traits S aureus has acquired since the introduction of antimicrobial chemotherapy in the 1930s, meticillin resistance is clinically the most important, since a single genetic element confers resistance to the most commonly prescribed class of antimicrobials—the ß-lactam antibiotics, which include penicillins, cephalosporins, and carbapenems.

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