Pulmonary Complications of Sickle Cell Disease  

Oleh:

Gladwin, Mark T. ; Vichinsky, Elliott

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 359 no. 21 (Nov. 2008), page 2254.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2008.06 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The inheritance of two copies of a mutant ß-globin gene, one from each parent, is the underlying cause of sickle cell disease. The mutation, GAG->GTG, substitutes valine for glutamic acid at position 6 in the ß-globin chain of hemoglobin A, resulting in a hemoglobin called hemoglobin S.1,2,3 Sickle cell disease is one of the most common autosomal recessive disorders in the world. Approximately 8% of black Americans are heterozygous and have the sickle cell trait, whereas approximately 1 in 600 is homozygous and has sickle cell disease. In certain areas of sub-Saharan Africa, an estimated 40 to 60% of . . .

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