Perbedaan Kadar PSA dan TGF-Beta1 Terhadap Pemberian Kombinasi Inhibitor 5alfa-Reduktase (Dutasteride) dan Anti Estrogen (tamoxifen) pada Pasien BPH LUTS  

Oleh:

Prasetyo, Rachmat Budi ; Soetojo ; Soebadi, Doddy M. ; Hendromartono ; Retnowati, Endang ; Widayat S. ; Widodo JP.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Jurnal Urologi Indonesia (Indonesian Journal of Urology) vol. 15 no. 02 (Jul. 2008), page 43.
Topik: PSA; TGF-Beta1; tamoxifen; dutasteride

Ketersediaan

Perpustakaan FK Nomor Panggil: J33.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Objective: To compare the PSA and TGF-beta1 plasma levels before and after administration of a 5 alpha-reductase inhibitor (dutasteride) and an anti estrogen (tamoxifen) in nonobstructive patient with BPH. Material and method: We enrolled 40 patients with a diagnosis o BPH without urinary retension. Patients were allocated into 4 groups of 10 patients and were given tamoxifen, dutasteride, a combination of tamoxifen and dutasteride, or placebo. We measured PSA and TGF-Beta1 plasma levels at study entry and 3 month after administration. Data were analysed using SPSS 12. Results: Increase of TGF-Beta1, as high as 54%(2,18+-0,88 to 3,36+-1,06) in the tamoxifen group, 26% (2,75+-0,62 to 3,47+-0,82) in the dutasteride group, and 92%(2,37+-0,75 to 4,56+-1,98) in the combination group, was significant(p<0,05). PSA was not significantly decrease in all groups(p>0,05). PSA decrease 28%(4,25+-3,28 to 3,06+-3,08) in the tamoxifen group, 27%(2,20+-2,17 to 1,60+-0,982) in the dutasteride group, and 19%(2,95+-1,22 to 2,40+-1,78) in the combination group. In the placebo group was no significant difference of both parameters. Conclusion: TGF-Beta1 was significantly increase in all groups except in placebo. PSA was decrease in all groups but not significant statistically. We concluded that TGF-Beta1 may better be used as a biomarker in the evaluation and management of BPH than PSA.

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