Zinc deficiency in Mexican American children: influence of zinc and other micronutrients on T cells, cytokines, and antiinflammatory plasma proteins  

Oleh:

Sandstead, Harold H ; Prasad, Ananda S. ; Penland, James G ; Beck, Frances WJ ; Kaplan, Joseph

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 88 no. 04 (Oct. 2008), page 1067.

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2008.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective:We measured the effects of zinc and micronutrients or of micronutrients alone on indexes of cell-mediated immunity and antiinflammatory plasma proteins. Design:Subjects (n = 54) aged 6-7 y were randomly assigned and treated in double-blind fashion in equal numbers with 20 mg Zn (as sulfate) and micronutrients or with micronutrients alone 5 d/wk for 10 wk. Results:Before treatment the mean ± SD plasma zinc was 14.9 ± 1.7 µmol/dL and the range was within the reference; hair zinc was 1.78 ± 0.52 µmol/g and 41.6% were =1.68 µmol/g; serum ferritin was 25.7 ± 18.6 µg/L and 50.0% were =20 µg/L. The zinc and micronutrients treatment increased the lymphocyte ratios of CD4+ to CD8+ and of CD4+CD45RA+ to CD4+CD45RO+, increased the ex vivo generation of interleukin-2 (IL-2) and interferon-{gamma} (IFN-{gamma}), decreased the generation of interleukin-10 (IL-10), and increased plasma interleukin-1 receptor antagonist (sIL-1ra) and soluble tumor necrosis factor receptor 1 (sTNF-R1). Micronutrients alone increased the ratio of CD4+ to CD8+ but not of CD4+CD45RA+ to CD4+CD45RO+, increased IFN-{gamma} but had no effect on IL-2 or IL-10, and increased sIL-1ra but not sTNF-R1. Efficacy of zinc and micronutrients was greater than micronutrients alone for all indexes except the ratio of CD4+ to CD8+, which was affected similarly. Conclusions:Before treatment, concentrations of hair zinc in 41.6% of subjects and serum ferritin in 50% were consistent with the presence of zinc deficiency. The greater efficacy of the zinc and micronutrients treatment compared with micronutrients alone supports this interpretation.

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