Changes in bone mineral status and bone size during pregnancy and the influences of body weight and calcium intake  

Oleh:

Olausson, Hanna ; Laskey, M Ann ; Goldberg, Gail R ; Prentice, Ann

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 88 no. 04 (Oct. 2008), page 1032.

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2008.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Calcium may be mobilized from the maternal skeleton during pregnancy, which may be influenced by several factors. Objective: The objective was to investigate changes in bone mineral status and size during pregnancy and to consider the influences of body weight and calcium intake. Design: Thirty-four British women were studied before pregnancy and 2 wk postpartum (Preg). Eighty-four nonpregnant, nonlactating (NPNL) women were studied over a corresponding time. Bone mineral content (BMC), bone area (BA), areal bone mineral density (aBMD), and BA-adjusted BMC of the whole-body, lumbar spine, radius, and hip were measured by dual-energy X-ray absorptiometry. Results: The Preg group experienced significant decreases in BMC, aBMD, and BA-adjusted BMC at the whole-body, spine, and total hip of between 1% and 4%. Whole-body BMC increased in the NPNL group, and aBMD and BA-adjusted BMC decreased at the spine and hip by 0.5% to 1%. Whole-body BMC decreased in the Preg group by –2.16 ± 0.46%, equivalent to –2.71 ± 0.43% relative to the NPNL group (P = 0.001). Weight change was a positive predictor of skeletal change at the spine, hip, and radius in both groups. Differences between the Preg and NPNL groups in change in BA-adjusted BMC, after correction for weight change and other influences, were as follows (P = 0.01): whole-body, –1.70 ± 0.25%; spine, –3.03 ± 0.72%; and total hip, –1.87 ± 0.60%. Calcium intake was not a significant predictor of skeletal change in either group. Conclusions: Pregnancy is associated with decreases in whole-body and regional bone mineral status sufficient to make a sizeable contribution to maternal and fetal calcium economy. Calcium intake is not a significant predictor of the skeletal response to pregnancy in well-nourished women

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