The extract "shoe flower" (Hibicus rosea sinensis L) leaves inhibit the spermatogenesis of ddy strain mice  

Oleh:

Mawuntu, Margaretha

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Medical Journal of Indonesia vol. 17 no. 03 (Jul. 2008), page 157.
Topik: spermatogonia; Pachiten primary spermatoctes; spermatids

Ketersediaan

Perpustakaan FK Nomor Panggil: M35.K.2008.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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This study was conducted in order to develop male contracetion from plant, namely the "shoe flower" (hibiscus rosea sinensis L ) leaves. The objective of this study was to find out whether the extract if "shoe flower" leaves could inhibit the process of spermatogenesis on ddy strain mice. This research was perfomed in 3 groups and each group consisted of 8 mice. The control group was given 1% carboxy methyl cellulose (CMC) in 0.5 ml aquabides. The treatment group I wasgiven the extract of "shoe flower" leaves 700 mg/kg BW and 0.5 ml aquabides. The treatment weregiven for 40 days in accodance with the spermatogenesis cycle. Them, the production of histological slides of the mice testis and the obsevation of the slides using light microscope with magnification of 100x and 400x were done. further, counting of the spermatogenic cells was done. At last the Picture of seminiferous tubulus cross-section of the three groups which consisted of the spermatogenic cells were taken through light miscroscope with magnification of 10x and 400x using Fuji camera and Fuji film, 200 ASA. The results showed significant diffrences between the control, treatment I, and treatment II group. There were decreased number of spermatogonia, pachyten primary spermatocytes and spermatids in treatmnet groups (P<0.01). the result of this study showed that extract of "shoe flower" (Hibiscus rosea sinensis L) Leaves, inhibited the process of spermatogenesis of ddy strain mice. It is hoped that the result of this study can be developed into a male contraception

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