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BukuAnalysis of Breast Cancer Microarray Data and Partial Reconstruction of Relevant Regulatory Networks
Bibliografi
Author: Eric, Tang Man-Hung
Topik: Breast Cancer; Microarray Analysis; Gene
Bahasa: (EN )    
Penerbit: International Masters Program in Bioinformatics Chalmers University of Technology     Tempat Terbit: Göteborg    Tahun Terbit: 2005    
Jenis: Theses - Master Thesis
Fulltext: 5_Analysis of breast cancer microarray data and partial reconstruction of relevant regulatory networks.pdf (1.7MB; 2 download)
Abstract
Using traditional clustering in microarray analysis, one can now identify homogeneous groups of genes that co-express similarly. Parallel gene monitoring becomes essential to understand gene expression regulatory mechanisms, especially in the case of diseases. Furthermore, recent studies introduced subspace clustering using the Gene Ontology, yielding clusters of genes with similar biological function. In our work we propose to combine these two methods to investigate genes involved in apparition of breast cancer. We believe that isolating subclusters of genes similar both in expression patterns and functions may provide valuable information on their regulation.
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