Pengaruh Sitotoksik Ekstrak Buah Mahkotadewa [Phaleria macrocarpa (Scheff) Boerl.] Terhadap Sel Kanker Lestari HeLA  

Oleh:

Pertamawati

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: JSTI: Jurnal Sains dan Teknologi Indonesia vol. 9 no. 1 (Apr. 2007), page 39-43.
Topik: Pengaruh Sitotoksik; Ekstrak Buah Mahkotadewa; Sel HeLA

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: SS57.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Fruits of mahkotadewa [Phaleria macrocarpa (Scheff) Boerl.] has been used to cure various health problems, including empirical treatment fior cancer. The therapeutic effect of natural material is related to the chemical compounds it contain. In fruits of Phaleria macrocarpa, various chemicals are present such as falvonoid and tannin, both show anticancer activity, as well as other unknown ones presumably supportive for cancer treatment. An in vitro experiment is then set up with the objective of examining the effect of fruit extract on human uterine cervical carcinoma cells (HeLA cells). Various concentrations: 5, 10, 15, 25, 50, and 100 ppm of fruit extract were evaluated. Observations were made 24, 72 and 120 hour after incubating HeLA cells in each tretments. The result showed that fruit might inhibit the growth of HeLA cells. Inhibitory concentration (IC50) of fruit extraxt after 24 hour of incubation is 6,21 ppm, after 72 hour of incubation is 5,09 ppm and 5,73 ppm after 120 hour of incubation. Inhibitory potential of fruit in 72 hour of incubation is a highest ones. The effect might be associated to the active compounds contained in these material.

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