Pengaruh Pemberian Ekstrak Biji Klabet (Trigonella foenum-graceum L.) Terhadap Perkembangan Uterus Tikus Putih Betina Galur Wistar Prepubertal  

Oleh:

Agustini, Kurnia ; Wiryowidagdo, Sumali ; Kusmana, Dadang

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: JSTI: Jurnal Sains dan Teknologi Indonesia vol. 9 no. 1 (Apr. 2007), page 8-16.
Topik: Berat Basah Uterus; Biji Klabet; Endometrium; Fito estrogen; Tikus Prepubertal; Trigonella foenum-graceum L.

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: SS57.1 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Phytoestrogen is the chemical compound contains in plant which has estrogenic like effect. Estrogen has important function on woman's sexual organ, such as proliferation of uterine and vaginal comification. Phytoestrogen are weak agonists for estrogen and illicit statistic significantly increases in uterine wet weight, at define dose, in uterotrophic bioassay. Biji Klabet or Fenugreek (Trigonella foenum-graceum L.) contains steroidal sapogenins such as, diosgenin, tigogenin, gitogenin, yamogenin, and trigoneoside, that suspected having an estrogen-likeeffect or as phytoestrogen. The aim of this research was to investigate the estrogenic effect of the fenugreek's ethanolic extract in immature rat models. These models represent the climacteric/menopause phase, there estrogen level is very low because ovary produces no estrogen. The testing animals were divided into five groups, namely normal group, estradiol control froup and three level doses of fenugreek extract (30mg/200g BW; 60mg/200g BW and 120mg/200g BW). The result indicated that on 120mg/200g BW, fenugreek extract significantly increasing wet weight uterine and proliferation of uterine, such as uterine thickness and uterina diameters. Fenugreek extract, start on 60mg/200g BW also induces vaginal lubrication and estrus cycle.

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