How HIV Guts the Immune System  

Oleh:

Johnson, R. Paul

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 358 no. 21 (May 2008), page 2287-2289.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2008.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Although in the absence of treatment, the acquired immunodeficiency syndrome (AIDS) generally develops 8 to 10 years after infection with human immunodeficiency virus (HIV) type 1 (HIV-1), the onslaught on the immune system by HIV-1 begins with the rapid depletion of memory CD4+ T cells, the majority of which reside in the gut. A recent report by Arthos et al.1 suggests that HIV-1 is able to mediate depletion of gut CD4+ T cells in part by co-opting the molecule that helps direct T cells to the gut: the integrin 4ß7.

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