Detail Selective delayed alternation deficits in dominantly inherited olivopontocerebellar atrophy   Oleh:  Robitaille, Yves ; Kish, Stephen ; El-Awar, Munir ; Freedman, Morris ; Schut, Lawrence ; Oscar-Berman, Marlene Jenis: Article from Bulletin/Magazine Dalam koleksi: Brain and Cognition vol. 16 no. 2 (Jul. 1991), page 121-129. Ketersediaan Perpustakaan PKBB Nomor Panggil: 405/BAC/16 Non-tandon: tidak ada Tandon: 1  Lihat Detail Induk Isi artikel In order to characterize more completely the nature of the frontal lobe-type cognitive changes in patients with dominantly inherited olivopontocerebellar atrophy (OPCA) we administered two tasks sensitive to frontal system dysfunction, delayed alternation (DA) and delayed response (DR), to 12 patients from one OPCA family. Affected members from this family have previously been shown to have a marked and widespread cerebral (including frontal) cortical cholinergic reduction as severe as that observed in Alzheimer's disease. Performance on DA, but not on DR, was significantly impaired in the OPCA patients compared to that in the controls. We suggest that the DA deficits in OPCA could be a consequence of a loss of cholinergic innervation to orbitofrontal or possibly temporal cortical areas and/or damage to the integrity of the cerebellofrontal neuronal connections. @ 1991 Academic Press, Inc. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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