Detail Wei, Lin and Weissfeld’s marginal analysis of multivariate failure time data: should it be applied to a recurrent events outcome? Bibliografi Author: Metcalfe, Chris ; Thompson, Simon G. Bahasa: (EN )    Edisi: Apr 2007     Penerbit: SAGE Publications      Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 103SMMR162SP.pdf (759.14KB; 0 download) Abstract Wei, Lin and Weissfeld (WLW) have applied an elaboration of Cox’s proportional hazards regression to the analysis of recurrent events data. This application is controversial and has attracted criticism in a piecemeal fashion over 15 years. A frequently raised concern is the method’s ‘risk set’: each individual is considered to be at risk of all recurrent events from the start of the observation period. The WLW method often gives estimates that exceed those provided by alternative approaches. This paper investigates whether the estimates are a consequence of biased estimation, or reflect a particular aspect of the treatment effect. Simulation studies showthat theWLWmethod infringes the proportional hazards assumption when applied to recurrent events data, but that the bias thismay cause is not behind the distinctive effect estimates. Instead, the method’s risk set is demonstrated to be responsible, leading to discussion of the interpretation of the treatment effect being estimated. Analyses of medical data indicate that the infringement of the proportional hazards assumption is not necessarily greater than that experienced with other applications of proportional hazards regression and need not prohibit the application of WLW’s method to recurrent events data. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

Copyright © 2006, 2007 Unika Atma Jaya, all rights reserved