Immunoparalysis and Adverse Outcomes from Critical Illness  

Oleh:

Frazier, W. Joshua ; Hall, Mark W.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Pediatric Clinics of North America vol. 55 no. 03 (Jun. 2008), page 647.

Ketersediaan

Perpustakaan FK Nomor Panggil: P13.K.2008.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Proper immunologic balance between pro- and anti-inflamatory forces is necessary for recovery from critical illness. Persistence of a marked compensatory anti-inflamatory innate immune response after an insult is termed immunoparalysis. Critically ill patients demonstrating prolonged, severe reductions in monocyte HLA-DR expression or ex vivo tumor necrosis factor alfa production are at high risk for nosocomial infection and death. Reversal ofimmunoparalysis can be accomplished through the administration of immunostimulatory agents or tapering of exogenous immunosuppresion. Evidence suggests that may be associated with improved clinical outcomes. Immune-monitoring protocols are needed to indentify patients who may benefit from immunomodulatory trials.

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