Aliskiren and Dual Therapy in Type 2 Diabetes Mellitus  

Oleh:

Ingelfinger, Julie R.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 358 no. 23 (Jun. 2008), page 2503.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2008.03 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

The discovery 110 years ago that crude kidney extract elicited a pressor reaction provided the first evidence of the existence of the renin–angiotensin–aldosterone system, a major vasoactive system,1 and the complex actions and interactions of this important cascade are still unfolding. Over the past few decades, various components of the renin–angiotensin–aldosterone system have been elucidated more completely, and previously unknown members have been discovered.2 Drugs that specifically block various components of the renin–angiotensin–aldosterone system have been developed (Figure 1). Angiotensin-converting–enzyme (ACE) inhibitors block the conversion of angiotensin I to angiotensin II, and clinically available angiotensin-receptor blockers block the . . .

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