Activated Protein C and Diabetic Nephropathy  

Oleh:

Gilbert, Richard E. ; Marsden, Philip A.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The New England Journal of Medicine (keterangan: ada di Proquest) vol. 358 no. 15 (Apr. 2008), page 1628.

Ketersediaan

Perpustakaan FK Nomor Panggil: N08.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Medical students are taught that endothelial dysfunction is relevant to the pathophysiology of diabetic microvascular disease, especially the glomerular defects that are characteristic of diabetic nephropathy. The facts, however, belie a paucity of knowledge about the molecular biology of the glomeruli of humans with type 1 or type 2 diabetes. Which genes are activated in the glomerular endothelial cells of patients with long-term diabetes? Which genes are abnormally suppressed? The extent of our ignorance is impressive. Fortunately, a study recently reported by Isermann et al.1 remedies, at least in small part, this deficit. As a consequence of their unique position . . .

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