Maternal Insulin Therapy Increases Fetal Endothelial Progenitor Cells During Diabetic Pregnancy  

Oleh:

Fadini, Gian Paolo ; Baesco, Ilenia ; Agostini, Carlo ; Cuccato, Emily ; Nardelli, Giovanni Battista ; and Others

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 31 no. 04 (Apr. 2008), page 808.
Topik: EPC; endothelial progenitor cell; GDM; gestational diabetes mellitus

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Endothelial progenitor cells (EPCs) are bone marrow-derived cells involved in endothelial homeostatis and angiogenesis. Reduction and dysfunction of EPCs have been associated with the development of atheroslcerosis and diabetic complications(1,2). Recent studies in human pregnancies suggest that a mother's EPCs are involved in the physiologic vascular remodeling of systemic and untero-plancetal circulation, causing maladaptive responses during diabetic pregnancies. Indeed, EPCs have been shown to be dysregulated in pregnant women with diabetes (4). Little is known about the effects of maternal factors on fetal EPCs. One study showed reduced cord bloodEPCs in severe eclampsia (6), but there were no data on diabetes. This study was undertaken to evaluate quantitative alterations of cord blood progenitors cells during diabetic pregnancies.

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