Metabolic and Immunological Features of the Failing Islet-Transplanted Patient  

Oleh:

Fiorina, Paolo ; Vergani, Andrea ; Petrelli, Alessandra ; D'Addio, Francesca ; Monti, Lucilla ; and Others

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Diabetes Care vol. 31 no. 03 (Mar. 2008), page 436.
Topik: HOMA-IR; homeostasis model assessment of insulin resistance ; long fx; long-term functioning graft ; sFasL; soluble FasL ; short fx; short-term functioning graft ; sIL-2r; soluble interleukin-2 receptor

Ketersediaan

Perpustakaan FK Nomor Panggil: D05.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

OBJECTIVE—This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure. RESEARCH DESIGN AND METHODS—We measured several metabolic and immunological markers at the time of pretransplant and several time points posttransplantation in 17 patients with long-term functioning graft (long fx) and 20 patients with short-term functioning graft (short fx). RESULTS—The short fx group showed higher insulin resistance, altered proinsulin processing, lower soluble interleukin-2 receptor (sIL-2r) (marker of T-cell activation), and higher soluble FasL (marker of apoptosis) during the entire follow-up, particularly at time of failure. CONCLUSIONS—Patients who experienced an early failure of islet allograft showed specific metabolic and immunological signs long before islet failure.

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