Effects of -lactalbumin–enriched formula containing different concentrations of glycomacropeptide on infant nutrition  

Oleh:

Sandstrom, Olof ; Lonnerdal, Bo ; Graverholt, Gitte ; Hernell, Olle

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 87 no. 04 (Apr. 2008), page 921.

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Formula-fed infants have growth and plasma amino acid patterns different from those of breastfed infants. Objective: -Lactalbumin is a major protein in human milk, and the addition of bovine -lactalbumin to infant formula has been proposed to modify the plasma amino acid pattern of the recipient infant, possibly allowing a reduction in the protein content of the formula, which may affect growth. Design: We compared breastfed infants and infants fed standard formula or -lactalbumin–enriched formulas (25% of protein) with glycomacropeptide accounting for 15% or 10% of the protein. The protein content of each formula was 13.1 g/L. Ninety-six infants aged 6 ± 2 wk were recruited. Anthropometric measures were recorded, and interviews were conducted at enrollment and monthly until 6 mo of age. Blood samples were collected at enrollment and at 4 and 6 mo. Results: Formula intake did not differ between groups, and weight gain in the -lactalbumin–enriched formula groups were similar to that of the breastfed infants. The standard formula group gained significantly more weight than did the breastfed infants. All formula-fed infants had significantly higher plasma concentrations of most essential amino acids at 4 and 6 mo than did the breastfed infants, and serum urea nitrogen was also higher in the formula-fed infants. Insulin and leptin concentrations did not differ between groups. Conclusions: Compared with standard formula-fed infants, infants fed formula with a modified protein composition had growth patterns more similar to those of breastfed infants. All formula-fed groups had plasma amino acid concentrations similar to or higher than those of breastfed infants. This indicates that the protein content of -lactalbumin–enriched formula can be further reduced, which should be evaluated.

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