Dehydroepiandrosterone (DHEA) and Intracrinology  

Oleh:

Liben, Paulus

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Majalah Ilmu Faal Indonesia vol. 06 no. 01 (Oct. 2006), page 14.
Topik: intracrinology; DHEA; androgens; menopause

Ketersediaan

Perpustakaan FK Nomor Panggil: M07.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Dehydroepiandrosterone (DHEA) is a prohormone secreted in large amounts by the adrenals in humans. It is secreted in larger quantities than cortisol and is present in the blood at consentrations only second to cholesterol. DHEA is transformed into androgens and/or estrogens in peripheral target tissue, thus permitting all androgen sensitive and estrogen sensitive tissue to make locally and control the intracellular level of sex steroids according to local needs. This new field of endocrinology has been called intracinology. In women, after menopouse, all estrogens and almost all androgens are made locally in peripheral tissue from DHEAwhich indirectly exerts effects, among others, on bone formation, adiposity, muscle, insuline and glucose metabolism, skin, libido and well-being. In men, where the secretion of androgens by testicles continues for life, the contribution of DHEA to androgens has been best evaluated in the prostate where about 50% of androgens are made locally from DHEA. The new field of intracrinology or local formation of sex steroids from DHEA in target tissue has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potensial use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering excitting possibilities for women's health at menopause

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