Hubungan Orkidektomi dan Detorsi dengan Respon Imun Testis Kontralateral pada Torsio Testis  

Oleh:

Ongkorahardjo, Edwin ; Hardjowijoto, Sunaryo ; Soetojo ; Sudiana, Ketut ; Widodo J.P.

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Jurnal Urologi Indonesia (Indonesian Journal of Urology) vol. 15 no. 01 (Jan. 2008), page 1-6.
Topik: Testicular torsion; immune response; detorsion; Orchiectomy

Ketersediaan

Perpustakaan FK Nomor Panggil: J33.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Objective : To study the effects of orchiectomy and detorsion in contralateral testicular immune response after unilateral testicular torsion. Materials and Methods : Forty eight testes from rattus norwegicus strain wistar white rats underwent 720o unilateral left testicular torsion. The experimental animals were divided into 6 groups : 2 groups had sham operations which served as controls, 2 groups had ligation of the left testicular torsion with subsequent orchiectomy at 4 and 24 hours, 2 groups had ligation left testicular torsion followed by detorsion at 4 and 24 hours. Contralateral testes examined after 7 days for IL-4 producing lymphocytes and immunoglobulin G-producing plasma cells in contralateral testes by immunohistochemistry. Results : Multivariate analysis results revealed that after unilateral left testicular torsio followed by detorsion at 24 hours group IL-4 and IgG had entered intratubular tissue and was significantly different from orchiectomy and control groups (p=0,0001 and p=0,0001). This indicated that damage of germinal epithelium in contralateral testes was caused by immuno;ogic response stimulated by detorsion. In left testicular torsion and orchiectomy or detorsion at 4 hours, sample did not show both intratubular IL-4 and IgG and found no significant difference of both IL-4 and IgG in extratubules among orchiectomy, detorsion and control group (p=0,326 and p=0,064). This indicated that in 4 hours immune response were not significantly different between those group groups and germinal epithelium were still intact. Conclusion : Detorsion in 24 hours testicular torsion had stimulated immune response which caused damage of germinal epithelium in contralateral testis. In 4 hours testicular torsion immune response happened not significantly different between detorsion, orchiectomy and control.

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