Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the Combined Abciximab REteplase Stent Study in Acute Myocardial Infarction (CARESS-in-AMI) : an open, prospective, randomised, multicentre trial  

Oleh:

Mario, Carlo Di ; Dudek, Dariusz ; Piscione, Federico ; Mielecki, Waldemar ; Sovonitto, Stefano ; and Others

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Lancet (keterangan: ada di Proquest) vol. 371 no. 9612 (Feb. 2008), page 559.

Ketersediaan

Perpustakaan FK Nomor Panggil: L01.K.2008.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Background Thrombolysis remains the treatment of choice in St-segment elevation myocardial infarction (STEMI) when primary percutaneous coronary intervention (PCI) cannot be done within 90 min. However, the best subsequent management of patients after thrombolytic therapy remains unclear. To assess the best management, we randomised patients with STEMI treated by thrombolysis and abciximab at a non interventional hospital to immediate transfer for PCI, or to standard medical therapy with transfer for rescue angioplasty. Methods 600 patients aged 75 years or younger with one or more high risk features (extensive ST-segment elevation, new onset left bundle branch block, previous myocardial infarction, Killip class >2, or left ventricular ejection fraction <35%)in hospital in France, Italy, and Poland were treated with half-dose reteplase, abciximab, heparin, and aspirin, and randomly assigned to immidiate transfer to the nearest interventional centre for PCI, or to management in the local hospital with transfer only in case of persistent ST-segment elevation or clinical deterioration. the primary outcome was a composite of death, reinfarction, or refractory ischaemia 30 days, and analysis was by intention to treat. Findings Of the 299 patients assigned to immediate PCI, 289 (97·0%) underwent angiography, and 255 (85·6%) received PCI. Rescue PCI was done in 91 patients (30·3%) in the standard care/rescue PCI group. The primary outcome occurred in 13 patients (4·4%) in the immediate PCI group compared with 32 (10·7%) in the standard care/rescue PCI group (hazard ratio 0·40; 95% CI 0·21–0·76, log rank p=0·004). Major bleeding was seen in ten patients in the immediate group and seven in the standard care/rescue group (3·4% vs 2·3%, p=0·47). Strokes occurred in two patients in the immediate group and four in the standard care/rescue group (0·7% vs 1·3%, p=0·50). Interpretation Immediate transfer for PCI improves outcome in high-risk patients with STEMI treated at a non-interventional centre with half-dose reteplase and abciximab.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali