Comparison between high density lipoprotein, lipoprotein(a) and small dense low lipoprotein as a risk marker of coronary heart disease  

Oleh:

Priyana, Adi

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Universa Medicina vol. 26 no. 01 (Jan. 2007), page 11.
Topik: coronary heart disease; LDL cholesterol; Lp(a) and small dense LDL

Ketersediaan

Perpustakaan FK Nomor Panggil: U01.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background Coronary heart disease (CHD) is still the primary cause of death in Indonesia and most industrialized countries. Atherosclerosis is the most common cause of CHD. The conventional risk factor for atherosclerosis and CHD are diabetes mellitus, hypertension, dyslipidemia and smoking. On the other hand, Lp(a) and small dense LDL (sd-LDL) have been considered as novel risk factors for CHD. High density lipoprotein (HDL) cholesterol (HDL-c), as part of dyslipidemia, has been considered as independent risk factor for CHD. The principal objective of the present study was to compare between HDL-c, Lp(a) and sdl LDL as a risk marker of CHD. Methods The study subject were divided into two groups, risk group consist of 94 subjects who had ³ 2 CHD risk factors and control group recruited 49 subject who had no CHD risk factors. Both groups had fasted for 10-12 hours before their sera were collected. The sera were examined for HDL-c, Lp(a) and sd-LDL. Three alternative multivariate models were compared sd-LDL, sd-HDL + HDL-c, and sd-LDL, HDL-c + Lp(a). Results Result of this study showed that the sd-LDL had the most significant and accurate as risk marker for CHD. Lp(a) and HDL-c were less accurate if used as risk marker for CHD compare with sd-LDL. Conclusions Small dense LDL is an accurate risk marker for CHD. Further study must be done using larger sample size of CHD subjects with similar age between risk and control groups.

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