Role of serologic bone marker in osteoporosis management  

Oleh:

Priyana, Adi

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI - non-atma jaya
Dalam koleksi: Universa Medicina vol. 26 no. 03 (Jul. 2007), page 152.
Topik: osteoporosis; bone marker; osteocalcin; P1-NP dan ß-crossLaps

Ketersediaan

Perpustakaan FK Nomor Panggil: U01.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Osteoporosis is a skeletal disorder with reduced bone density and strength. This lead increased risk of fracture. Osteoporosis can be classified as primary and secondary osteoporosis. Primary osteoporosis is found in menopaused women due to reduced estrogen hormone, and in men due to reduced calcium. Many primary diseases can cause secondary osteoporosis. Bone mass density can be considered as a standard examination for osteoporosis but it is still controversial because it need more than 2 years to differentiate bone mass. But bone marker examination can give description of remodelling process in bones only for 3–6 months, such as bone resorption by osteoclast and bone formation by osteoblasts. Bone marker analysis can support the diagnosis of osteoporosis, therapeutic response, identify the causal factors, select the mode of therapy, and study the pathogenesis of osteoporosis. In this review some bone markers such as alkaline phosphatase (ALP), osteocalcin, P1-NP, and b-CrossLaps and their use in osteoporosis will be described. Keywords: Osteoporosis, bone marker, osteocalcin, P1-NP dan ß-CrossLaps

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