Detail Pharmacology and Pharmacokineticsof Amiodarone Bibliografi Author: Freedman, Michael D. ; Somberg, John C. Bahasa: (EN )     Jenis: Article - diterbitkan di jurnal ilmiah internasional Fulltext: 1061.pdf (1.52MB; 0 download) Abstract Amiadarone is a unique antiarrhythmic agent originally developed as a vasadilator. Classified electrophysiologically as a Type 111 antiarrhythmic, it also has both nonspecific antisympathetic and direct, fast channel-membrane effects. Hemadynamic effects of orally administered amiodarone (a negative inotropic agent) are usually negligible, and are usually compensated for by induced vasodilatian, Effects an thyroid and hepatic function may help to explain same of the unique pharmacologic as well as toxicologic effects of the drug. Amiodarone is poorly bioavailable (20-80%) and undergoes extensive enterohepatic circulation before entry into a central compartment. The principal metabalite, mono-n-desethyl amiadarone is also an antiarrhythmic. From this central compartment, it undergoes extensive tissue distribution (exceptionally high tissue/plasma partition coefficients). The distribution half-life of amiadarone out of the central compartment to peripheral and deep tissue compartments (tl/2,,) may be as short as 4 hours. The terminal half-life (t#{189}0) is both long and variable (9-77 days) secondary to the slow mobilization of the lipophilic medication out of (primarily) adipocytes. A phormocokinetically and data suggesting a role for routine amiadarane plasma levels are presented. based loading scheme is described, and data suggesting a role for routine amiadarane plasma levels ore presented. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

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