Detail Requirement of Inositol Pyrophosphates for Full Exocytotic Capacity in Pancreatic ß Cells   Oleh:  Illies, Christopher ; Gromada, Jesper ; Fiume, Roberta ; Leibiger, Barbara ; Jia, Yu ; and Others Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 318 no. 5854 (Nov. 2007), page 1299. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.09 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Inositol pyrophosphates are recognized components of cellular processes that regulate vesicle trafficking, telomere length, and apoptosis. We observed that pancreatic ß cells maintain high basal concentrations of the pyrophosphate diphosphoinositol pentakisphosphate (InsP7 or IP7). Inositol hexakisphosphate kinases (IP6Ks) that can generate IP7 were overexpressed. This overexpression stimulated exocytosis of insulin-containing granules from the readily releasable pool. Exogenously applied IP7 dose-dependently enhanced exocytosis at physiological concentrations. We determined that IP6K1 and IP6K2 were present in ß cells. RNA silencing of IP6K1, but not IP6K2, inhibited exocytosis, which suggests that IP6K1 is the critical endogenous kinase. Maintenance of high concentrations of IP7 in the pancreatic ß cell may enhance the immediate exocytotic capacity and consequently allow rapid adjustment of insulin secretion in response to increased demand. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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