Evolution of genes and Genomes on The Drosophila Phylogeny  

Oleh:

Clark, Andrew G. ; Eisen, Michael B. ; Smith, Douglas R. ; Bergman, Casey M. ; Oliver, Brian ; and Others

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: NATURE (keterangan: ada di Proquest) vol. 450 no. 7167 (Nov. 2007), page 203.

Ketersediaan

Perpustakaan FK Nomor Panggil: N01.K.2007.10 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust result than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), ilustrate how rates and pattern of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanism of development, cell biology, genetics, disease, neurobiology, behaviou, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non neutral changes in protein coding genes, non coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.

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