Detail A synthetic approach toward paclitaxel analogs from (S)-(+)-carvone Bibliografi Author: Lo, Ho Yin ; Shing, T.K.M. (Advisor) Topik: CHEMISTRY; ORGANIC Bahasa: (EN )    ISBN: 0-599-69299-5     Penerbit: CHINESE UNIVERSITY OF HONG KONG (PEOPLE'S REPUBLIC OF CHINA)     Tahun Terbit: 2000     Jenis: Theses - Dissertation Fulltext: 9964828.pdf (0.0B; 0 download) Abstract In this thesis, a review concerning the development of the clinical drug Paclitaxel (Taxol®) and the chemical syntheses of this natural product from 1960 to 1999 is presented. Synthetic studies on the construction of Paclitaxel ABC-ring skeleton via the type 2 Intramolecular Diels-Alder (IMDA) reaction are described. The synthesis adopts a C→ABC ring formation strategy. Three kinds of precursors (a precursor with electron deficient diene, a precursor with normal electronic demand, and a precursor with electron deficient dienophile) were synthesised from R-(–)-carvone and S-(+)-carvone through an acid catalysed intermolecular Diels-Alder reaction with isoprene. The investigation of the type 2 IMDA reaction reveals the importance of the C-2 ketone and the problem of elimination reaction of the C-10 benzyl group during the reaction, leading to undesirable side products. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Lihat Sejarah Pengadaan  Konversi Metadata   Kembali

Copyright © 2006, 2007 Unika Atma Jaya, all rights reserved