Characteristics of Treatment Na?ve Chronic Hepatitis B in Bangladesh : Younger Population are More Affected; HBeAg-negatives are More Advanced  

Oleh:

Alam, Shahinul ; Ahmad, Nooruddin ; Mustafa, Golam ; Alam, Khorshed ; Khan, Mobin

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The Saudi Journal of Gastroenterology vol. 14 no. 01 (Jan. 2008), page 15.
Topik: Age; Bangladesh; Chronic hepatitis B

Ketersediaan

Perpustakaan FK Nomor Panggil: T02.K.02 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background / Aim : Bangladesh is a densely populated country with intermediate endemicity for chronic hepatitis B (CHB). The aim of the present study was evaluate the biochemical, virological, and histological character of CHB patients and to examine the relationship between these indices. Materials and Methods : One thousand and twenty-two patients of CHB fulfilled our inclusion criteria. Inclusion criteria were (1) HBsAg-positive for at least 6 month, (2) HBeAg-positive or negative and (3) hepatitis B virus (HBV) DNA positive. Patients with detectable antibodies to human immunodeficiency virus (HIV), Hepatitis Delta virus (HDV) or Hepatitis C virus (HCV), with previous antiviral treatment, overt cirrhosis and hepatocellular carcinoma, were excluded. Of these, 191 patient were randomly selected for liver biopsy and were evaluated for analysis. Results : In the 191 patients, male to female ratio was 4.6:1; age distribution was 26.5 ± 8.5 (mean ± standard deviation) years. One hundred and seventy-eight (93.2%) patients were under 40 years. Sixty-eight (35.6%) patients were HBeAg-negative, had less DNA load, and were significantly older, more fibrotic and cirrhotic (P<0.001). Correlation was not found between DNA level and histological activity.Histological activity was not correlated with ALT level in HBeAg-positive patients (P < 0.001). Conclusion : CHB affects the younger population in Bangladesh. HBeAg-positive CHB was associated with more fibrosis and cirrhosis. Serum HBV DNA levels do not correlate with the severity of histological lesions an all patients. Evaluation by liver biopsy gold standard for taking decision of treatment.

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