Change Page : In patients allergic to penicillin, consider second and third generation cephalosporins for life threatening infections  

Oleh:

Pegler, Scott ; Healy, Brendan

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: British Medical Journal (keterangan: ada di Proquest) vol. 335 no. 7627 (Nov. 2007), page 991.

Ketersediaan

Perpustakaan FK Nomor Panggil: B16.K.2007.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Key points True penicillin allergy occurs in 7-23% of patients who give a history of penicillin allergy The frequently cited figure of 10% cross reactivity between penicillin and cephalosporins is an overestimate Cross reactivity between penicillins and second and third generation cephalosporins is low and may be lower than the cross reactivity between penicillins and unrelated antibiotics Anaphylaxis with cephalosporins is rare (0.1-0.0001%) In life threatening infections such as bacterial meningitis, septicaemia, and severe respiratory tract infections, consider using second and third generation cephalosporins even in patients with a history of penicillin allergy The clinical problem Many patients claim to be allergic to penicillin. For those confirmed as being truly allergic (type 1 allergy, with features of urticaria, pruritic rash, etc), the cited overall rate of 10% cross reactivity between penicillin and cephalosporins is an overestimate.1 For life threatening infections such as bacterial meningitis, septicaemia, and severe respiratory tract infections in which a non-cephalosporin antibiotic . . .

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