Dose response to vitamin D supplementation among postmenopausal African American women  

Oleh:

Talwar, Sonia A. ; Aloia, John F. ; Pollack, Simcha ; Yeh, James K.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: The American Journal of Clinical Nutrition vol. 86 no. 06 (Dec. 2007), page 1657.
Topik: Ethnicity ; vitamin D ; 25-hydroxyvitamin D ; osteoporosis ; vitamin D deficiency ; African Americans

Ketersediaan

Perpustakaan FK Nomor Panggil: A07.K.2007.04 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Background: Reports on the dose response to vitamin D are conflicting, and most data were derived from white men and women. Objective: The objective was to determine the response of serum 25-hydroxyvitamin D [25(OH)D] to oral vitamin D3 supplementation in an African American population. Design: Healthy black postmenopausal women (n = 208) participated in a vitamin D3 supplementation trial for a period of 3 y. Analyses were done in the vitamin D supplementation arm (n = 104) to quantify the response in serum 25-hydroxyvitamin D concentrations at a steady state vitamin D input. The participants received 20 µg/d (800 IU) oral vitamin D3 for the initial 2 y and 50 µg/d (2000 IU) for the third year. Results: Supplementation with 20 µg/d (800 IU/d) vitamin D3 raised the mean serum 25(OH)D concentration from a baseline of 46.9 ± 20.6 nmol/L to 71.4 ± 21.5 nmol/L at 3 mo. The mean (±SD) concentration of serum 25(OH)D was 87.3 ± 27.0 nmol/L 3 mo after supplementation increased to 50 µg/d (2000 IU/d). All participants achieved a serum 25(OH)D concentration >35 nmol/L, 95% achieved a concentration >50 nmol/L, but only 60% achieved a concentration >75 nmol/L. All patients had concentrations <153 nmol/L. On the basis of our findings, an algorithm for prescribing vitamin D so that patients reach optimal serum concentrations was developed. The algorithm suggests a dose of 70 µg (2800 IU/d) for those with a concentration >45 nmol/L and a dose of 100 µg (4000 IU/d) for those with a concentration <45 nmol/L. Conclusions: Supplementation with 50 µg/d (2000 IU/d) oral vitamin D3 is sufficient to raise serum 25-hydroxyvitamin D concentrations to >50 nmol/L in almost all postmenopausal African American women. However, higher doses were needed to achieve concentrations >75 nmol/L in many women in this population.

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