The Metabolic Effect of Progesterone : Magnificent Phenomenon In Glucose Metabolism and Insulin Regulation During Pregnancy  

Oleh:

Bambang Purwanto

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Majalah Ilmu Faal Indonesia vol. 06 no. 02 (Feb. 2007), page 129.
Topik: Progesterone; glucose; insulin

Ketersediaan

Perpustakaan FK Nomor Panggil: M07.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Progesterone levels rise during pregnancy, starting from embryo implantation until 32nd week of gestational. The metabolic effect of progesterone is associated with gestational diabetes, his been primaly attributed to its negative effects on insulin sensitivy. Since progesterone receptors (PR) were identified in beta cells of pancreas, progestrone segnaling was studied, to explain it effect on insulin regulation and glucose metabolism. More recently, progesterone effect was time dependent; acute progesterone treatment can enhance insulin secretion to adapt for the decrease in insulin sensitivity. However, beta cell function and GLUT4 expression appears to be reduced on chronic exposure to progesterone in vivo.

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