Peroxisome Proliferator Activated Receptor (PPAR)  

Oleh:

Anwar Ma'ruf

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Majalah Ilmu Faal Indonesia vol. 06 no. 02 (Feb. 2007), page 111.
Topik: PPARs; Insulin Sensitivity; ß-Oxidation

Ketersediaan

Perpustakaan FK Nomor Panggil: M07.K Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

Peroxisome Proliferator Activated Receptor (PPAR) is a group of transcription factors that elaborates correlation between lipid or glucose availability wuth long-term metabolic-adaptation. It has been recently recognized that there are three PPAR isoforms, PPARa, PPARg and PPARd/b, signaled by different genes. PPAR has an important role in lipid and carbohydrate metabolism as well as regulating glucocorticoid action and inflammatory cytokines. Peroxisome proliferator activated receptor alpha (PPARa) is expressed in hepatocyte, cardiomyocyte, renal cortex, skeletal muscle, and enterocyte. PPARg is particularly expressed in adipose tissue and immune cells, while PPARd is ubiquitously expressed in various sites, even in higher amount than the two other PPARs. PPARa activation may increase fatty acid oxidation in heart, liber and, in lesser degree, in skeletal muscle. PPARa activation also induces glucose saving through the increase of PDK4 expression or, indirectly, through the increase of keton bodies synthesis and fatty acid oxidation capacity. The increase of the latter elaborates the lipid lowering effects of fibric acid and in certain circumstances improves insulin sensitivity by reducing lipid accumulation in tissues.

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