Karakterisasi Rekristalit Antalgin-Fenilbutason dengan Pelarut Aseton sebagai Suatu Sistem Interaksi Fisika  

Oleh:

Ilma Nugrahani ; Ibrahim, Slamet ; Soewandhi, Sundani Nurono ; Asyarie, Sukmadjaja

Jenis: Article from Journal - ilmiah nasional - terakreditasi DIKTI
Dalam koleksi: Jurnal Ilmu Kefarmasian Indonesia vol. 05 no. 01 (Apr. 2007), page 37 - 44.
Topik: antalgyne; phenybutazone; recrystallization; acetone; polymorphism; solvatomorphims; peritecticum

Ketersediaan

Perpustakaan FK Nomor Panggil: J27.K.01 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Recrystallization with acetone of antalgyne, phenylbutazone, and the mixture of binary system has been characterized. The aim of this research was looking for thermodynamic and x ray diffraction characteristic of re-crystallite to compare with raw material characteristics. The result used to confirm validity of cool contact methods to identify physical interaction of antalgine-phenylbutazone that has been developed in the preliminary research. Recrystallites characterized by DSC and powder XRD shows the polymorphism cases, but the co recrystallite of binary system show the peritecticum physical interaction, similar with the physical interaction of the raw material binary syatem before recrystallization. Principally. the result of this investigation prove that cool contact methods by acetone could be used for identify physical interaction of antalgine-phenylbutazone.

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