Meta-analysis of Gene-environment Interactions In Developmental Psychopathology  

Oleh:

Taylor, Alan ; Kim-Cohen, Julia

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: Development and Psychopathology vol. 19 no. 4 (2007), page 1029-1037.
Topik: Psychopathology; Developmental Psychopathology; Meta-analysis of Gene-environment
Fulltext: 1029.pdf (298.01KB)

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: DD21.13 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

As studies of measured gene-environment interactions (GxE) in developmental psychopathology gain momentum, methods for systematically and quantitatively summarizing effects across multiple studies are urgently needed. Meta-analyses of GxE findings are critical for evaluating the overall statistical and theoritical significance of any given GxE based on cummulative and systematically combined knowledge. Although meta-analytic methods for the combination of study findings based on single effect measures such as odds ratios and mean differences are well established, equivalent methods for the meta-analysis of studies investigating interactions are not well developed. This article describes one simple approach to the meta-analysis of GxE effects using, as a contemporaneous example, the interaction of the monoamine oxidase A (MAOA) gene and the impact of childhood maltreatment on risk for developing antisocial behavior.

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