Detail Human Genome Ultraconserved Elements Are Ultraselected   Oleh:  Katzman, Sol ; Kern, Andrew D. ; Bejerano, Gill ; Fewell, Ginger ; Fulton, Lucinda ; Wilson, Richard K. ; Salama, Sofie R. ; Haussler, David Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 317 no. 5840 (Aug. 2007), page 915. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.07 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Ultraconserved elements in the human genome are defined as stretches of at least 200 base pairs of DNA that match identically with corresponding regions in the mouse and rat genomes. Most ultraconserved elements are noncoding and have been evolutionarily conserved since mammal and bird ancestors diverged over 300 million years ago. The reason for this extreme conservation remains a mystery. It has been speculated that they are mutational cold spots or regions where every site is under weak but still detectable negative selection. However, analysis of the derived allele frequency spectrum shows that these regions are in fact under negative selection that is much stronger than that in protein coding genes. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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