Metabolisme Homosistein dan Hubungannya dengan Penyakit Vaskuler  

Oleh:

Usman, Herman

Jenis: Article from Journal - ilmiah nasional - tidak terakreditasi DIKTI
Dalam koleksi: Widya: Majalah Ilmiah vol. 24 no. 266 (Nov. 2007), page 48-57.
Topik: Homocysteine; Vascular Disease; Metabolisme Homosistein

Ketersediaan

Perpustakaan Pusat (Semanggi) Nomor Panggil: MM47.26 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk
Perpustakaan PKPM Nomor Panggil: W36 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada	Lihat Detail Induk

Isi artikel

Homocysteine is formed from the essential, sulphur containing amino acid methionine. Methionine may be "regenerated” from homocysteine in the so-called remethylation reaction by the enzyme methionine synthase. Homocysteine may also be “degraded” in the so-called transsulphuration reaction into cysteine. Most of the homocysteIne in blood is either oxidised and occurs as different disulfides or covalently bound to proteins, predo-minantly albumin. High blood kadars of homocysteine signal a breakdown in this vital process, resulting in far-reaching biochemical and life consequences. The link between homocysteine and cardiovascular, peripheral vascular and other vascular disease is well established, and decreasing plasma total homocysteine by providing nutritional cofactors for its metabolism has been shown to reduce the risk of vascular events. Significant deficiencies in the homocysteine remethylation cofactors cobalamin (B12) and folate, as well as the trans-sulfuration cofactor vitamin.

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