Detail Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange   Oleh:  Kolfschoten, Marijn van der Neut ; Schuurman, Janine ; Losen, Mario ; Bleeker, Wim K. ; Martinez-Martinez, Pilar ; and Others Jenis: Article from Bulletin/Magazine Dalam koleksi: SCIENCE (keterangan: ada di Proquest) vol. 317 no. 5844 (Sep. 2007), page 1554. Ketersediaan Perpustakaan FK Nomor Panggil: S01.K.2007.08 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada     Lihat Detail Induk Isi artikel Antibodies play a central role in immunity by forming an interface with the innate immune system and, typically, mediate proinflammatory activity. We describe a novel posttranslational modification that leads to anti-inflammatory activity of antibodies of immunoglobulin G, isotype 4 (IgG4). IgG4 antibodies are dynamic molecules that exchange Fab arms by swapping a heavy chain and attached light chain (half-molecule) with a heavy-light chain pair from another molecule, which results in bispecific antibodies. Mutagenesis studies revealed that the third constant domain is critical for this activity. The impact of IgG4 Fab arm exchange was confirmed in vivo in a rhesus monkey model with experimental autoimmune myasthenia gravis. IgG4 Fab arm exchange is suggested to be an important biological mechanism that provides the basis for the anti-inflammatory activity attributed to IgG4 antibodies. Opini Anda Klik untuk menuliskan opini Anda tentang koleksi ini! Kembali

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