Differential Notch signalling distinguishes neural stem cells from intermediate progenitors  

Oleh:

Ken-ichi Mizutani ; Keejung Yoon ; Dang, Louis ; Okinori, Tokunaga ; Gaiano, Nicholas

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: NATURE (keterangan: ada di Proquest) vol. 449 no. 7160 (Sep. 2007), page 351.

Ketersediaan

Perpustakaan FK Nomor Panggil: N01.K.2007.09 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The existence of different proliferative cell types in most stem cell systems is widely accepted, but the differences between these stem cells and restricted progenitor subsets are poorly understood. Now a team working at Johns Hopkins has discovered how two distinct cell populations in the developing mouse brain — 'true' neural stem cells and similar but less potent progenitors — are distinguished. The stem cells undergo stepwise maturation, gradually shedding 'stem cell' properties. The first step turns stem cells into 'progenitors' by dictating how signals downstream of Notch, a protein that regulates stem cells in many tissues, are transmitted. Then the two cell types diverge and the key factor here is whether a Notch signalling protein called CBF1 is active or not. CBF1 signalling plays the same role in blood stem cells, so it may be be a general 'switch' distinguishing stem cells from progenitors.

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