Autoimmune disease : Skin deep but complex  

Oleh:

Baumgarth, Nicole ; Bevins, Charles L.

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: NATURE (keterangan: ada di Proquest) vol. 449 no. 7162 (Oct. 2007), page 551.

Ketersediaan

Perpustakaan FK Nomor Panggil: N01.K, N01.K.2007.09 Non-tandon: 2 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

The aberrant activation of plasmacytoid dendritic cells (pDCs) to produce interferon can cause immune-mediated inflammation and disease development in psoriasis. A trigger for this effect has now been identified in the form of the human antimicrobial peptide LL37, which is found in the skin of psoriasis patients, and in damaged skin. Also known as CAMP, this peptide converts otherwise non-stimulatory self-DNA released by dying cells into a potent activator of interferon production in pDCs. These findings point to a possible role for LL37 overexpression in driving autoimmune skin inflammation in psoriasis and potentially other related diseases. LL37 antagonists may therefore be effective against inflammatory diseases, and LL37 itself may be a useful vaccine adjuvant.

Opini Anda

Klik untuk menuliskan opini Anda tentang koleksi ini!

Kembali