Plasmacytoid dendritic cells sense self-DNA couple wiyh antimicrobial peptide  

Oleh:

Lande, Roberto ; Gregorio, Josh ; Facchinetti, Valeria ; Chatterjee, Bithi ; Yi-Hong, Wang ; and Others

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: NATURE (keterangan: ada di Proquest) vol. 449 no. 7162 (Oct. 2007), page 564.

Ketersediaan

Perpustakaan FK Nomor Panggil: N01.K, N01.K.2007.09 Non-tandon: 2 (dapat dipinjam: 0) Tandon: tidak ada

Lihat Detail Induk

Isi artikel

Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but this restriction seems to break down in human autoimmune disease by an as yet poorly understood mechanism. Here we identify the antimicrobial peptide LL37 (also known as CAMP) as the key factor that mediates pDC activation in psoriasis, a common autoimmune disease of the skin. LL37 converts inert self-DNA into a potent trigger of interferon production by binding the DNA to form aggregated and condensed structures that are delivered to and retained within early endocytic compartments in pDCs to trigger Toll-like receptor 9. Thus, our data uncover a fundamental role of an endogenous antimicrobial peptide in breaking innate tolerance to self-DNA and suggest that this pathway may drive autoimmunity in psoriasis.

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