MicroRNA control of nodal signalling  

Oleh:

Martello, Graziano ; Zacchigna, Luca ; Inui, Masafumi ; Montagner, Marco ; Adorno, Maddalena ; and Others

Jenis: Article from Journal - ilmiah internasional
Dalam koleksi: NATURE (keterangan: ada di Proquest) vol. 449 no. 7159 (Sep. 2007), page 183.

Ketersediaan

Perpustakaan FK Nomor Panggil: N01.K.2007.09 Non-tandon: 1 (dapat dipinjam: 0) Tandon: tidak ada

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Isi artikel

MicroRNAs are crucial modulators of gene expression, yet their involvement as effectors of growth factor signalling is largely unknown. Ligands of the transforming growth factor- superfamily are essential for development and adult tissue homeostasis. In early Xenopus embryos, signalling by the transforming growth factor- ligand Nodal is crucial for the dorsal induction of the Spemann's organizer. Here we report that Xenopus laevis microRNAs miR-15 and miR-16 restrict the size of the organizer by targeting the Nodal type II receptor Acvr2a. Endogenous miR-15 and miR-16 are ventrally enriched as they are negatively regulated by the dorsal Wnt/-catenin pathway. These findings exemplify the relevance of microRNAs as regulators of early embryonic patterning acting at the crossroads of fundamental signalling cascades.

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